Early Estimates of Bivalent mRNA Vaccine Effectiveness in Preventing COVID-19–Associated Emergency Department or Urgent Care Encounters and Hospitalizations Among Immunocompetent Adults — VISION Network, Nine States, September–November 2022

Weekly / December 30, 2022 / 71(5152);1616–1624

On December 16, 2022, this report was posted online as an MMWR Early Release.

Mark W. Tenforde, MD, PhD1; Zachary A. Weber, PhD2; Karthik Natarajan, PhD3,4; Nicola P. Klein, MD, PhD5; Anupam B. Kharbanda, MD6; Edward Stenehjem, MD7; Peter J. Embi, MD8,9; Sarah E. Reese, PhD2; Allison L. Naleway, PhD10; Shaun J. Grannis, MD9,11; Malini B. DeSilva, MD12; Toan C. Ong, PhD13; Manjusha Gaglani, MBBS14,15; Jungmi Han3; Monica Dickerson1; Bruce Fireman, MA5; Kristin Dascomb, MD, PhD7; Stephanie A. Irving, MHS10; Gabriela Vazquez-Benitez, PhD12; Suchitra Rao, MBBS13; Deepika Konatham16; Palak Patel, MBBS1; Kristin E. Schrader, MA2; Ned Lewis, MPH5; Nancy Grisel, MPP7; Charlene McEvoy, MD12; Kempapura Murthy, MBBS16; Eric P. Griggs, MPH1; Elizabeth A. K. Rowley, DrPH2; Ousseny Zerbo, PhD5; Julie Arndorfer, MPH7; Margaret M. Dunne, MSc2; Kristin Goddard, MPH5; Caitlin Ray, MPH1; Yan Zhuang, PhD2; Julius Timbol, MS5; Morgan Najdowski, MPH17; Duck-Hye Yang, PhD2; John Hansen, MPH5; Sarah W. Ball, ScD2; Ruth Link-Gelles, PhD17(VIEW AUTHOR AFFILIATIONS)View suggested citation


What is already known about this topic?

Bivalent mRNA COVID-19 booster doses containing an Omicron BA.4/BA.5 sublineage component were recommended on September 1, 2022. The effectiveness of these updated vaccines against COVID-19–associated medical encounters has not been established.

What is added by this report?

Bivalent booster doses provided additional protection against COVID-19–associated emergency department/urgent care encounters and hospitalizations in persons who previously received 2, 3, or 4 monovalent vaccine doses. Because of waning of monovalent vaccine-conferred immunity, relative effectiveness of bivalent vaccines was higher with increased time since the previous monovalent dose.

What are the implications for public health practice?

All persons should stay up to date with recommended COVID-19 vaccinations, including receiving a bivalent booster dose if eligible.

American father loses parental rights after ex-wife announces their child is transgender

Had to share this from Wintery Knight. This is a wake up call to all.

A while back, I blogged about a case in Canada, where a father was imprisoned for objecting to the forced transgendering of his child by the schools,…

American father loses parental rights after ex-wife announces their child is transgender