Ivermectin, a potential anticancer drug derived from an antiparasitic drugMingyang Tang, Xiaodong Hu, […], and Qiang Fang

Graphical abstract

Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.

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Abbreviations: ASC, Apoptosis-associated speck-like protein containing a CARD; ALCAR, acetyl-L-carnitine; CSCs, Cancer stem cells; DAMP, Damage-associated molecular pattern; EGFR, Epidermal growth factor receptor; EBV, Epstein-Barr virus; EMT, Epithelial mesenchymal-transition; GABA, Gamma-aminobutyric acid; GSDMD, Gasdermin D; HBV, Hepatitis B virus; HCV, Hepatitis C virus; HER2, Human epidermal growth factor receptor

SOURCE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/

Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth

Shican Zhou 1Hang Wu 1Wenjuan Ning 1Xiao Wu 1Xiaoxiao Xu 1Yuanqiao Ma 1Xingwang Li 1Junhong Hu 1Chenyu Wang 1Junpeng Wang 1

Affiliations expand

Free PMC article

Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. Ivermectin, an antiparasitic drug, has been shown to possess anti-inflammation, anti-virus, and antitumor properties. However, whether ivermectin affects CRC is still unclear. The objective of this study was to evaluate the influence of ivermectin on CRC using CRC cell lines SW480 and SW1116. We used CCK-8 assay to determine the cell viability, used an optical microscope to measure cell morphology, used Annexin V-FITC/7-AAD kit to determine cell apoptosis, used Caspase 3/7 Activity Apoptosis Assay Kit to evaluate Caspase 3/7 activity, used Western blot to determine apoptosis-associated protein expression, and used flow cytometry and fluorescence microscope to determine the reactive oxygen species (ROS) levels and cell cycle. The results demonstrated that ivermectin dose-dependently inhibited colorectal cancer SW480 and SW1116 cell growth, followed by promoting cell apoptosis and increasing Caspase-3/7 activity. Besides, ivermectin upregulated the expression of proapoptotic proteins Bax and cleaved PARP and downregulated antiapoptotic protein Bcl-2. Mechanism analysis showed that ivermectin promoted both total and mitochondrial ROS production in a dose-dependent manner, which could be eliminated by administering N-acetyl-l-cysteine (NAC) in CRC cells. Following NAC treatment, the inhibition of cell growth induced by ivermectin was reversed. Finally, ivermectin at low doses (2.5 and 5 µM) induced CRC cell arrest. Overall, ivermectin suppressed cell proliferation by promoting ROS-mediated mitochondrial apoptosis pathway and inducing S phase arrest in CRC cells, suggesting that ivermectin might be a new potential anticancer drug therapy for human colorectal cancer and other cancers.

Keywords: apoptosis; cell cycle; colorectal cancer; ivermectin; oxidative stress.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1 The chemical structure of ivermectin…
FIGURE 2
FIGURE 2 Ivermectin inhibits cell proliferation of…
FIGURE 3
FIGURE 3 The effect of ivermectin on…
FIGURE 4
FIGURE 4 Ivermectin induced apoptosis in colorectal…
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FIGURE 5 Effect of ivermectin on Caspase…

SOURCE: https://pubmed.ncbi.nlm.nih.gov/34483925/

Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes

Na Li and Xianquan Zhan

Additional article information

Associated Data

Supplementary Materials

Abstract

Relevance

Ivermectin, as an old anti-parasite drug, can suppress almost completely the growth of various human cancers, including ovarian cancer (OC). However, its anticancer mechanism remained to be further studied at the molecular levels. Ivermectin-related molecule-panel changes will serve a useful tool for its personalized drug therapy and prognostic assessment in OCs.

Purpose

To explore the functional significance of ivermectin-mediated lncRNA-EIF4A3-mRNA axes in OCs and ivermectin-related molecule-panel for its personalized drug therapy monitoring.

Methods

Based on our previous study, a total of 16 lncRNA expression

SOURCE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272521/#!po=1.31579

States look for solutions as U.S. fentanyl deaths keep rising

NATIONAL

States look for solutions as U.S. fentanyl deaths keep rising

by: GEOFF MULVIHILL, Associated Press

Posted: Apr 5, 2022 / 12:34 AM CDT

Updated: Apr 5, 2022 / 12:50 AM CDT

Source

https://www.borderreport.com/news/national/states-look-for-solutions-as-u-s-fentanyl-deaths-keep-rising/

As the addiction and overdose crisis that has gripped the U.S. for two decades turns even deadlier, state governments are scrambling for ways to stem the destruction wrought by fentanyl and other synthetic opioids.

In statehouses across the country, lawmakers have been considering and adopting laws on two fronts: reducing the risk to users and increasing the penalties for dealing fentanyl or mixing it with other drugs. Meanwhile, Republican state attorneys general are calling for more federal action, while some GOP governors are deploying National Guard units with a mission that includes stopping the flow of fentanyl from Mexico.

“It’s a fine line to help people and try to get people clean, and at the same time incarcerate and get the drug dealers off the streets,” said Nathan Manning, a Republican state senator in Ohio who is sponsoring legislation to make it clear that materials used to test drugs for fentanyl are legal.

The urgency is heightened because of the deepening impact of the drugs. Last year, the U.S. Centers for Disease Control and Prevention reported the nation had hit a grim milestone. For the first time, more than 100,000 Americans had diedof drug overdoses over a 12-month period. About two-thirds of the deaths were linked to fentanyl and other synthetic drugs, which can be 50 to 100 times more potent than morphine, heroin or prescription opioids. Texas lawmakers failed to legalize fentanyl testing strips last year, but there’s still a push for access

The recent case of five West Point cadets who overdosed on fentanyl-laced cocaine during spring break in Florida put the dangers and pervasiveness of the fentanyl crisis back in the spotlight.

The chemical precursors to the drugs are being shipped largely from China to Mexico, where much of the illicit fentanyl supply is produced in labs before being smuggled into the U.S.

While users sometimes seek out fentanyl specifically, it and other synthetics with similar properties are often mixed with other drugs or formed into counterfeit pills so users often don’t know they’re taking it.

Advocates say test strips can help prevent accidental overdoses of drugs laced with fentanyl. The strips are given out at needle exchanges and sometimes at concerts or other events where drugs are expected to be sold or used.

Thomas Stuber, chief legislative officer at The LCADA Way, a drug treatment organization in Ohio that serves Lorain County and nearby areas, has been pushing for the test strip legislation. It also would ease access to naloxone, a drug that can be used to revive people when they’re having opioid overdoses.

“This is a harm-reduction approach that has received a lot of acceptance,” he said. “We cannot treat somebody if they’re dead.”

Since last year, at least a half-dozen states have enacted similar laws and at least a dozen others have considered them, according to research by the National Conference of State Legislatures.

In West Virginia, the state hardest hit by opioids per capita, lawmakers passed a bill this month to legalize the testing strips. It now heads to the governor.

The measure was sponsored by Republican lawmakers. But state Delegate Mike Pushkin, a Democrat whose district includes central Charleston, has also been pushing for more access to fentanyl strips. He said the situation got worse last year when a state law tightened regulations on needle exchanges, causing some of them to close.

Pushkin, who also is in long-term addiction recovery, is pleased with the passage of the testing strip bill but upset with another measure passed this month that would increase the penalties for trafficking fentanyl. That bill also would create a new crime of adding fentanyl to another drug.

“Their initial reaction is, ‘We have to do something,’” he said. “It’s not just about doing something, it’s about doing the right thing that actually has results.”

But for many lawmakers, making sure that tough criminal penalties apply to fentanyl is a priority.

California Assemblywoman Janet Nguyen, a Republican, introduced a measure that would make penalties for dealing fentanyl just as harsh as those for selling cocaine or heroin. The Republican represents Orange County, where there were more than 600 reported fentanyl-related deaths last year.

“This is sending messages to those who aren’t afraid of selling these drugs that there’s a longer, bigger penalty than you might think,” said Nguyen, whose bill failed to advance from her chamber’s public safety committee in a 5-2 vote last week. She said after the bill failed that she was considering trying again. 

She said committee members stressed compassion for drug users, something she said she agrees with.

“The less available these pills are out there, the better it is,” Nguyen said. “And that is going after the drug dealer.”DEA: We save lives in Middle America by stopping fentanyl at the border

The same day her measure failed to advance, a Democratic lawmaker in California announced a different bill to increase fentanyl-dealing penalties.

The National Conference of State Legislatures found 12 states with fentanyl-specific drug trafficking or possession laws as of last year. Similar measures have been introduced or considered since the start of 2021 in at least 19 states, the Associated Press found in an analysis of bills compiled by LegiScan. That does not include measures to add more synthetic opioids to controlled substance lists to mirror federal law; those have been adopted in many states, with bipartisan support.

Fentanyl has been in the spotlight in Colorado since February, when five people were found dead in a suburban Denver apartment from overdoses of fentanyl mixed with cocaine.

Under state law, possession with intent to distribute less than 14 grams of fentanyl is an offense normally punishable by two to four years in prison. But fentanyl is so potent that 14 grams can represent up to 700 lethal doses, under a calculation used by the U.S. Drug Enforcement Agency.

“It’s making it impossible to hold the dealer accountable for the deadliness of the drugs they’re peddling,” Colorado House Speaker Alec Garnett, a Democrat, said in an interview.In El Paso, fentanyl, an OD, and unknown reasons for Downtown jail deaths

He and a bipartisan group of lawmakers last week unveiled a bill also backed by Democratic Gov. Jared Polis that would increase penalties for dealers with smaller amounts of fentanyl and in cases where the drug leads to a death. The legislation also would increase the accessibility of naloxone and test strips while steering people who possess fentanyl into education and treatment programs.

Maritza Perez, director of national affairs at the Drug Policy Alliance, a group that advocates for harm-reduction measures, is skeptical of the legislation that would increase criminal penalties.

“We have the largest incarceration rate in the entire world and we’re also setting records in terms of overdose deaths,” she said.

Democratic governors are focusing primarily on harm reduction methods. Among them is Illinois Gov. Jay Pritzker, who released a broad overdose action plan last month.

Several Republican governors and attorneys general have responded to the rising death toll with administrative enforcement efforts and by pushing for more federal intervention.

Last year, Texas Gov. Greg Abbott and Arizona Gov. Doug Ducey called for states to help secure the border with Mexico. Along with trying to keep people from entering the U.S., stopping the flow of fentanyl was cited as a reason. Several other Republican governors have sent contingents of state troopers or National Guard units. 

The Texas Military Department said that from March 2021 through earlier this month, its troops near the border confiscated more than 1,200 pounds (540 kilograms) of fentanyl. By comparison, federal authorities reported confiscating about 11,000 pounds (4,990 kilograms) in 2021 — still a fraction of what entered the country.Gov. Greg Abbott brags about his border initiative. The evidence doesn’t back him up.

Last year, the U.S. Department of Justice filed about 2,700 cases involving crimes related to the distribution of fentanyl and similar synthetic drugs, up nearly tenfold from 2017. Even so, Republican state officials are critical of federal efforts to stop fentanyl from entering the country.

In January, 16 GOP state attorneys general sent a letter to U.S. Secretary of State Antony Blinken calling on him to exert more pressure on China and Mexico to stop the flow of fentanyl. Those are steps that Dr. Rahul Gupta, the director of National Drug Control Policy, said are already being taken.

In March, West Virginia Attorney General Patrick Morrisey called on U.S. Attorney General Merrick Garland for more enforcement on fentanyl trafficking and harsher penalties. 

“Fentanyl is killing Americans of all walks of life in unprecedented numbers,” Morrisey said in a statement emailed to the AP, “and the federal government must respond with full force, across the board, using every tool available to stem the tide of death.”

Copyright 2022 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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Unhealthy Landscapes: Policy Recommendations on Land Use Change and Infectious Disease Emergence

Unhealthy Landscapes: Policy Recommendations on Land Use Change and Infectious Disease Emergence

The could possibly be the rabbit hole from Hell… Some of it seems like it could make sense but that’s how the work. I wonder what one would find if they dug deep – real deep and followed the money Trail on this subject???

Anthropogenic land use changes drive a range of infectious disease outbreaks and emergence events and modify the transmission of endemic infections. These drivers include agricultural encroachment, deforestation, road construction, dam building, irrigation, wetland modification, mining, the concentration or expansion of urban environments, coastal zone degradation, and other activities. These changes in turn cause a cascade of factors that exacerbate infectious disease emergence, such as forest fragmentation, disease introduction, pollution, poverty, and human migration. The Working Group on Land Use Change and Disease Emergence grew out of a special colloquium that convened international experts in infectious diseases, ecology, and environmental health to assess the current state of knowledge and to develop recommendations for addressing these environmental health challenges.

The group established a systems model approach and priority lists of infectious diseases affected by ecologic degradation. Policy-relevant levels of the model include:

specific health risk factors, landscape or habitat change, and institutional (economic and behavioral) levels.

The group recommended creating Centers of Excellence in Ecology and Health Research and Training, based at regional universities and/or research institutes with close links to the surrounding communities.

The centers’ objectives would be 3-fold:

a) to provide information to local communities about the links between environmental change and public health;

b) to facilitate fully interdisciplinary research from a variety of natural, social, and health sciences and train professionals who can conduct interdisciplinary research; and

c) to engage in science-based communication and assessment for policy making toward sustainable health and ecosystems.

Human-induced land use changes are the primary drivers of a range of infectious disease outbreaks and emergence events and also modifiers of the transmission of endemic infections (Patz et al. 2000).

These land use changes include:

  • deforestation
  • road construction
  • agricultural encroachment
  • dam building
  • irrigation
  • coastal zone degradation
  • wetland modification
  • mining
  • the concentration or expansion of urban environments
  • and other activities.

These changes in turn cause a cascade of factors that exacerbate infectious disease emergence, such as forest fragmentation, pathogen introduction, pollution, poverty, and human migration. These are important and complex issues that are understood only for a few diseases. For example, recent research has shown that forest fragmentation, urban sprawl, and biodiversity loss are linked to increased risk for Lyme disease in the northeastern United States (Schmidt and Ostfeld 2001). Expansion and changes in agricultural practices are intimately associated with the emergence of Nipah virus in Malaysia (Chua et al. 1999; Lam and Chua 2002), cryptosporidiosis in Europe and North America, and a range of food-borne illnesses globally (Rose et al. 2001). Road building is linked to the expansion of bushmeat consumption that may have played a key role in the early emergence of human immunodeficiency virus types 1 and 2 (Wolfe et al. 2000), and simian foamy virus has been found in bushmeat hunters (Wolfe et al. 2004).

In recognition of the complexity of land use change and the risks and benefits to human health that it entails, a special colloquium titled “Unhealthy Landscapes: How Land Use Change Affects Health” was convened at the 2002 biennial meeting of the International Society for Ecosystem Health (6–11 June 2002, Washington, DC) to address this issue. The invited experts worked to establish consensus on the current state of science and identify key knowledge gaps underlying this issue. This article condenses the working group’s report and presents a new research and policy agenda for understanding land use change and its effects on human health. Specifically, we discuss land-use drivers or human activities that exacerbate infectious diseases; the land–water interface, common to many infectious disease life cycles; and conclusions and recommendations for research and training from the working group.

Land-Use Drivers of Infectious Disease Emergence

The emerging infectious diseases (EIDs) resulting from land use change can be entirely new to a specific location or host species. This may occur either from “spillover” or cross-species transmission or simply by extension of geographic range into new or changed habitats. More than 75% of human diseases are zoonotic and have a link to wildlife and domestic animals (Taylor et al. 2001).

The working group developed an extensive list of processes by which land use affects human health (specifically, infectious disease occurrence) and of other factors that contribute to this relationship: agricultural development, urbanization, deforestation, population movement, increasing population, introduction of novel species/pathogens, water and air pollution, biodiversity loss, habit fragmentation, road building, macro and micro climate changes, hydrological alteration, decline in public health infrastructure, animal-intensive systems, eutrophication, military conflict, monocropping, and erosion (ranked from highest to lowest public health impact by meeting participants). The four mechanisms that were felt to have the greatest impact on public health were changes to the physical environment; movement of populations, pathogens, and trade; agriculture; and urbanization. War and civil unrest were also mentioned as a potentially acute and cross-cutting driver. Infectious disease agents with the strongest documented or suspected links to land use change are listed in Table 1.

Changes to the biophysical environment.

Deforestation.

Rates of deforestation have grown exponentially since the beginning of the 20th century. Driven by rapidly increasing human population numbers, large swaths of species-rich tropical and temperate forests, as well as prairies, grasslands, and wetlands, have been converted to species-poor agricultural and ranching areas. The global rate of tropical deforestation continues at staggering levels, with nearly 2–3% of forests lost globally each year. Parallel with this habitat destruction is an exponential growth in human–wildlife interaction and conflict. This has resulted in exposure to new pathogens for humans, livestock, and wildlife (Wolfe et al. 2000). Deforestation and the processes that lead to it have many consequences for ecosystems. Deforestation decreases the overall habitat available for wildlife species. It also modifies the structure of environments, for example, by fragmenting habitats into smaller patches separated by agricultural activities or human populations. Increased “edge effect” (from a patchwork of varied land uses) can further promote interaction among pathogens, vectors, and hosts. This edge effect has been well documented for Lyme disease (Glass et al. 1995). Similarly, increased activity in forest habitats (through behavior or occupation) appears to be a major risk factor for leishmaniasis (Weigle et al. 1993). Evidence is mounting that deforestation and ecosystem changes have implications for the distribution of many other microorganisms and the health of human, domestic animal, and wildlife populations.

One example of the effects of land use on human health is particularly noteworthy. Deforestation, with subsequent changes in land use and human settlement patterns, has coincided with an upsurge of malaria and/or its vectors in Africa (Coluzzi 1984, 1994; Coluzzi et al. 1979), in Asia (Bunnag et al. 1979), and in Latin America (Tadei et al. 1998). When tropical forests are cleared for human activities, they are typically converted into agricultural or grazing lands. This process is usually exacerbated by construction of roads, causing erosion and allowing previously inaccessible areas to become colonized by people (Kalliola and Flores Paitán 1998). Cleared lands and culverts that collect rainwater are in some areas far more suitable for larvae of malaria-transmitting anopheline mosquitoes than are intact forests (Charlwood and Alecrim 1989; Jones 1951; Marques 1987).

Another example of the effects of land use on human health involves deforestation and noninfectious disease: the contamination of rivers with mercury. Soil erosion after deforestation adds significant mercury loads, which are found naturally in rainforest soils, to rivers. This has led to fish in the Amazon becoming hazardous to eat (Fostier et al. 2000; Veiga et al. 1994).

Habitat fragmentation.

This alters the composition of host species in an environment and can change the fundamental ecology of microorganisms. Because of the nature of food webs within ecosystems, organisms at higher trophic levels exist at a lower population density and are often quite sensitive to changes in food availability. The smaller patches left after fragmentation often do not have sufficient prey for top predators, resulting in local extinction of predator species and a subsequent increase in the density of their prey species. Logging and road building in Latin America have increased the incidence of cutaneous and visceral leishmaniasis (Desjeux 2001), which in some areas has resulted from an increase in the number of fox reservoirs and sandfly vectors that have adapted to the peridomestic environment (Patz et al. 2000). Foxes, however, are not very important reservoirs for leishmaniasis in Latin America (Courtenay et al. 2002), and a more important factor in the transmission cycle includes domestic dogs.

Ostfeld and Keesing (2000) have demonstrated that smaller fragments in North American forests have fewer small mammal predators. Results suggest that the probability that a tick will become infected depends on not only the density of white-footed mice but also the density of mice relative to that of other hosts in the community. Under this scenario, the density effect of white-footed mice, which are efficient reservoirs for Lyme disease, can be “diluted” by an increasing density of alternative hosts, which are less efficient at transmitting Lyme disease. These results suggest that increasing host diversity (species richness) may decrease the risk of disease through a “dilution effect” (Schmidt and Ostfeld 2001).

Extractive industries.

Gold mining is an extractive industry that damages local and regional environments and has adverse human health effects, because mercury is used to extract gold from riverbeds in the tropical forests. Not only does mercury accumulate in local fish populations, making them toxic to eat (Lebel et al. 1996, 1998), but mercury also suppresses the human immune system. Also, in gold-mining areas, more mosquito-breeding sites and increased malaria risk result from digging gem pits in the forest and from craters resulting from logging; broader disease spread occurs as populations disperse throughout the region (Silbergeld et al. 2002).

Movement of populations, pathogens, and trade.

The movement of humans, domestic animals, wildlife populations, and agricultural products through travel, trade, and translocations is a driver of infectious disease emergence globally. These sometimes inadvertent, sometimes deliberate movements of infectious disease and vectors (e.g., the introduction of smallpox and measles to the Americas by Spanish conquistadors) will continue to rise via continually expanding global travel and by development of Third World populations. Human introduction of pathogens, hosts, or materials into new areas has been termed “pathogen pollution” (Daszak et al. 2000).

Land use changes drive some of these introductions and migrations and also increase the vulnerability of habitats and populations to these introductions. Human migrations also drive land use changes that in turn drive infectious disease emergence. For example, in China’s Yunnan Province, an increase in livestock populations and migration has led to an increase in the incidence of schistosomiasis (Jiang et al. 1997). In Malaysia, a combination of deforestation, drought, and wildfires has led to alterations in the population movements and densities of flying foxes, large fruit bats known to be the reservoir for the newly emergent zoonosis Nipah virus (Chua et al. 1999). It is believed that the increased opportunity for contact between infected bats and pigs produced the outbreak of the disease in pigs, which then was transmitted to people in contact with infected pigs (Aziz et al. 2002).

Another example of human-induced animal movement on a much larger scale is the international pet trade. This movement of animals involves many countries and allows for the introduction of novel pathogens, such as monkeypox, with the potential to damage ecosystems and threaten human and animal health. Monkeypox was originally associated with bushmeat hunting of red colobus monkeys (Procolobus badius); after a localized epidemic emerged in humans, monkeypox persisted for four generations via human-to-human contact (Jezek et al. 1986).

Human movement also has significant implications for public health. Not only are travelers (tourists, businesspeople, and other workers) at risk of contracting communicable diseases when visiting tropical countries, but they also can act as vectors for delivering infectious diseases to another region or, in the case of severe acute respiratory syndrome (SARS), potentially around the world. Refugees account for a significant number of human migrants, carrying diseases such as hepatitis B and tuberculosis and various parasites (Loutan et al. 1997). Because of their status, refugees become impoverished and are more exposed to a wide range of health risks. This is caused by the disruption of basic health services, inadequate food and medical care, and lack of clean water and sanitation (Toole and Waldman 1997). People who cross international boundaries, such as travelers, immigrants, and refugees, may be at increased risk of contracting infectious diseases, especially those who have no immunity because the disease agents are uncommon in their native countries. Immigrants may come from nations where diseases such as tuberculosis and malaria are endemic, and refugees may come from situations where crowding and malnutrition create ideal conditions for the spread of diseases such as cholera, shigellosis, malaria, and measles [Centers for Disease Control and Prevention (CDC) 1998].

Zoonoses.

The importance of zoonotic diseases should be emphasized. Zoonotic pathogens are the most significant cause of EIDs affecting humans, both in the proportion of EIDs that they cause and in the impact that they have. Some 1,415 species of infectious organisms are known to be pathogenic to people, with 61% of them being zoonotic. Of the emerging pathogens, 75% are zoonotic, and zoonotic pathogens are twice as likely to be associated with emerging diseases than are nonzoonotic pathogens (Taylor et al. 2001). More important, zoonotic pathogens cause a series of EIDs with high case fatality rates and no reliable cure, vaccine, or therapy (e.g., Ebola virus disease, Nipah virus disease, and hantavirus pulmonary syndrome). Zoonotic pathogens also cause diseases that have some of the highest incidence rates globally [e.g., acquired immunodeficiency syndrome (AIDS)]. AIDS is a special case, because it is caused by a pathogen that jumped host from nonhuman primates and then evolved into a new virus. Thus, it is in origin a zoonotic organism (Hahn et al. 2000).

Because of the important role of zoonoses in current public health threats, wildlife and domestic animals play a key role in the process by providing a “zoonotic pool” from which previously unknown pathogens may emerge (Daszak et al. 2001). The influenza virus is an example, causing pandemics in humans after periodic exchange of genes among the viruses of wild and domestic birds, pigs, and humans. Fruit bats are involved in a high-profile group of EIDs that includes rabies and other lyssaviruses, Hendra virus and Menangle virus (Australia), and Nipah virus (Malaysia and Singapore), which has implications for further zoonotic disease emergence. A number of species are endemic to both remote oceanic islands and more populous suburban and rural human settlements; these may harbor enzootic and potentially zoonotic pathogens with an unknown potential for spillover (Daszak et al. 2000).

Thus, some of the current major infectious threats to human health are EIDs and reemerging infectious diseases, with a particular emphasis on zoonotic pathogens transferring hosts from wildlife and domestic animals. A common, defining theme for most EIDs (of humans, wildlife, domestic animals, and plants) is that they are driven to emerge by anthropogenic changes to the environment. Because threats to wildlife habitat are so extensive and pervading, many of the currently important human EIDs (e.g., AIDS, Nipah virus disease) are driven partly by human-induced changes to wildlife habitat such as encroachment and deforestation. This is essentially a process of natural selection in which anthropogenic environmental changes perturb the host–parasite dynamic equilibrium, leading to the expansion of those strains suited to the new environmental conditions and facilitating expansion of others into new host species (Daszak et al. 2001).

Agriculture.

Crop irrigation and breeding sites.

Agriculture occupies about half of the world’s land and uses more than two-thirds of the world’s fresh water (Horrigan et al. 2002). Agricultural development in many parts of the world has increased the need for crop irrigation, which reduces water availability for other uses and increases breeding sites for disease vectors. An increase in soil moisture associated with irrigation development in the southern Nile Delta after the construction of the Aswan High Dam has caused a rapid rise in the mosquito Culex pipiens and consequential increase in the arthropod-borne disease Bancroftian filariasis (Harb et al. 1993; Thompson et al. 1996). Onchocerciasis and trypanosomiasis are further examples of vector-borne parasitic diseases that may be triggered by changing land-use and water management patterns. In addition, large-scale use of pesticides has had deleterious effects on farm workers, including hormone disruption and immune suppression (Straube et al. 1999).

Food-borne diseases.

Once agricultural development has expanded and produced food sufficient to meet local need, the food products are exported to other nations, where they can pose a risk to human health. The increase in imported foods has resulted in a rise in food-borne illness in the United States. Strawberries from Mexico, raspberries from Guatemala, carrots from Peru, and coconut milk from Thailand have caused recent outbreaks. Food safety is an important factor in human health, because food-borne disease accounts for an estimated 76 million illnesses, 325,000 hospitalizations, and 5,200 deaths in the United States each year (CDC 2003). Other dangers include antibiotic-resistant organisms, such as Cyclospora, Escherichia coli O157:H7, and other pathogenic E. coli strains associated with hemolytic uremic syndrome in children (Dols et al. 2001).

Secondary effects.

Agricultural secondary effects need to be minimized, such as the emerging microbial resistance from antibiotics in animal waste that is included in farm runoff and the introduction of microdams for irrigation in Ethiopia that resulted in a 7-fold increase in malaria (Ghebreyesus et al. 1999).

Urbanization.

On a global basis, the proportion of people living in urban centers will increase to an unprecedented 65% by the year 2030 (Population Reference Bureau 1998). The 2000 census shows that 80% of the U.S. population now lives in metropolitan areas, with 30% living in cities of 5 million or more. The environmental issues posed by such large population centers have profound impacts on public health beyond the city limits (Knowlton 2001).

Alterations of ecosystems and natural resources contribute to the emergence and spread of infectious disease agents. Human encroachment of wildlife habitat has broadened the interface between wildlife and humans, increasing opportunities for both the emergence of novel infectious diseases in wildlife and their transmission to people. Rabies is an example of a zoonotic disease carried by animals that has become habituated to urban environments. Bats colonize buildings, skunks and raccoons scavenge human refuse, and in many countries feral dogs in the streets are common and the major source of human infection (Singh et al. 2001).

Infectious diseases can also pass from people to wildlife. Nonhuman primates have acquired measles from ecotourists (Wallis and Lee 1999). Also, drug resistance in gram-negative enteric bacteria of wild baboons living with limited human contact is significantly less common than in baboons living with human contact near urban or semiurban human settlements (Rolland et al. 1985).

The Land–Water Interface

Another major driver of infectious disease emergence results from the land–water interface. Land use changes often involve water projects or coastal marine systems in which nutrients from agricultural runoff can cause algal blooms.

Currently the seventh Cholera pandemic is spreading across Asia, Africa, and South America. In 1992, a new serogroup (Vibrio cholerae O139) appeared and has been responsible for epidemics in Asia (Colwell 1996). The seasonality of cholera epidemics may be linked to the seasonality of plankton (algal blooms) and the marine food chain. Studies using remote-sensing data of chlorophyll-containing phytoplankton have shown a correlation between cholera cases and sea surface temperatures in the Bay of Bengal. Interannual variability in cholera incidence in Bangladesh is also linked to the El Niño southern oscillation and regional temperature anomalies (Lobitz et al. 2000), and cholera prevalence has been associated with progressively stronger El Niño events spanning a 70-year period (Rodo et al. 2002). This observation on cholera incidence may represent an early health indicator of global climate change (Patz 2002).

Infectious diseases in marine mammals and sea turtles could serve as sentinels for human disease risk. Sea turtles worldwide are affected by fibropapillomatosis, a disease probably caused by one or several viruses and characterized by multiple epithelial tumors. Field studies support the observation that prevalence of this disease is associated with heavily polluted coastal areas, areas of high human density, agricultural runoff, and/or biotoxin-producing algae (Aguirre and Lutz, in press). This represents the breakdown of the land–water interface, to the point that several pathogens typical of terrestrial ecosystems have become established in the oceans. Toxoplasmosis in the endangered sea otter (Enhydra lutris) represents an example of pathogen pollution. Massive mortalities in pinnipeds and cetaceans reaching epidemics of tens of thousands are caused by four morbilliviruses evolving from the canine distemper virus (Aguirre et al. 2002). Additionally, overfishing has myriad ramifications for marine ecosystems and sustainable protein food sources for human populations.

Cryptosporidium, a protozoan that completes its life cycle within the intestine of mammals, sheds high numbers of infectious oocysts that are dispersed in feces. A recent study found that 13% of finished treated water still contained Cryptosporidium oocysts, indicating some passage of microorganisms from source to treated drinking water (LeChevallier and Norton 1995). The protozoan is highly prevalent in ruminants and is readily transmitted to humans. Thus, management of livestock contamination of watersheds is an important public health issue.

One example of how overexploitation of a natural water resource led to infectious disease is that of Lake Malawi in Africa. Overfishing in the lake reduced the population of snail-eating fish to such a level that snail populations erupted. Subsequently, schistosomiasis incidence and prevalence markedly rose after this ecologic imbalance (Madsen et al. 2001).

Recommendations from the Working Group

Conceptual model: bringing land use into public health policy.

The recommendations stemming from the international colloquium are highly relevant to the Millennium Ecosystem Assessment (MEA), a broad multiagency/foundation-sponsored scientific assessment of degraded ecosystem effects on human well-being. A conceptual framework of the MEA already provides an approach to optimize the contribution of ecosystems to human health (MEA 2003). This framework offers a mechanism to a) identify options that can better achieve human development and sustainable goals, b) better understand the trade-offs involved in environment-related decisions, and c) align response options at all scales, from the local to the global, where they can be most effective. This conceptual framework focuses on human well-being while also recognizing associated intrinsic values. Similar to the MEA, focus is particularly on the linkages between ecosystem services and human health. Workshop participants developed a conceptual model (Figure 1). Like the MEA, it assumes a dynamic interaction between humans and ecosystems that warrants a multiscale assessment (spatial and temporal).

By using this framework, policy makers may approach development and health at various levels. These levels include specific health risk factors, landscape or habitat change, and institutional (economic and behavioral) levels. For sound health policy, we must shift away from dealing primarily with specific risk factors and look “upstream” to underlying land-use determinants of infectious disease and ultimately the human behavior and established institutions that are detrimental to sustainable population health. The World Health Organization (WHO) has developed a similar DPSEEA (driving forces, pressures, state, exposure, effect, actions) model that in a similar way describes the interlinkage between human health and different driving forces and environmental change (WHO 1997).

As such understanding increases, it will become more feasible to plan how to prevent new infectious disease emergence. Yet, because these are rare events, accurate predictions will remain daunting. It is already evident that inserting humans into complex ecosystems can lead to a variety of EIDs, but health outcomes depend on the economic circumstances of the human population. In poor and tropical communities, land use change can lead to major shifts in infectious disease patterns. For these situations, many conventional public health interventions can prevent several infectious diseases at relatively low cost. In rich and temperate-climate communities, the infectious disease shifts tend to be more disease specific, for example, in the case of Lyme disease and habitat fragmentation.

Research on deforestation and infectious disease.

Considering the deforestation that usually accompanies agricultural development, new conservation-oriented agriculture should be pursued. As discussed above, water project development and modern livestock management present major health disease risks. However, often the secondary unintended consequences can also wreak havoc; for example, a leaking dam may present greater risks than the reservoir itself. A distressingly large number of development projects not only have adverse effects on human health but also fail to attain their primary economic purposes in a sustainable manner.

Habitat fragmentation, whether caused by forest destruction, desertification, or land-use conversion, affects human and wildlife health and ecosystem processes. There is already much research undertaken by landscape ecologists on the consequences of habitat fragmentation for wildlife, especially larger animals. It would be important to study the effects of landscape fragmentation on public health hazards. Such research could entail three components. The first component consists of gathering baseline data, including using historical data where possible and beginning monitoring programs where necessary. Key data include identifying and quantifying the relevant pathogen load of wildlife, livestock, and human communities in fragmented landscapes. The goals of this data collection are, first, to identify key infectious diseases, both chronic and emergent or reemergent and, second, to document the consequences of fragmentation on relative abundance of wildlife and subsequent pathogen load. For example, the loss of large predators in fragmented habitats in the northeastern United States has led to a superabundance of rodent vectors for Lyme disease.

The second component of the research program would involve health impact modeling, primarily in three areas: a) estimating changes in the relative abundance of organisms, including infectious disease vectors, pathogens, and hosts; b) projecting potential vector or transmission shifts (e.g., should the Nipah virus shift to pulmonary as well as neurologic expression in humans as in swine); and c) projecting the impact of infectious diseases in a region on different geographic scales.

The results of these analyses, if successful, could support the third component of research: development of decision-support tools. Improved decisions on land-use policy could be made from a better understanding of costs and benefits to health and environmental decision makers. In all probability, however, they will be very location specific. For example, to construct an irrigation scheme in India would likely invite a malaria epidemic, whereas the same activity in sub-Saharan Africa may have little effect on malaria transmission. It is worth mentioning that costs and benefits could depend on the time course over which they are assessed. For example, some land-use changes can lead to short-term increases in transmission followed by longer-term decreases (e.g., irrigation and malaria in Sri Lanka) or vice versa (e.g., deforestation and cutaneous leishmaniasis in Latin America).

Policies to reduce microbial traffic/pathogen pollution.

In today’s interconnected world, it becomes very important to invest in the worldwide control of infectious diseases in developing countries, for example. It is also necessary to control transport to stem the flow from one place to the next.

Improved monitoring of trade is warranted in order to target infectious disease introductions. In the attempt to prevent the invasion of a pathogen (and drug-resistant organisms) into the vulnerable areas subject to land use changes, we need to pay greater attention to controls at the sources. We need to document and map these trades and investigate the vectors, the infectious diseases they harbor, and the populations they threaten. Risk assessment should guide surveillance and the development of test kits, targeting point-of-origin intervention to preempt these processes. Assessments must further include nonmarket costs (usually to the detriment of the environment and long-term sustainable health). We should communicate to both the exporters and consumers the need to make their trades clean, economically viable, and certified “clean and green” by an independent scientific agency at the source and/or destination. Additionally, strategies for screening travelers for pathogens that may be introduced to a region should be improved.

Centers of Excellence in Ecology and Health Research and Training.

One approach to developing the issues to which this article draws attention is the creation of a system of regional- or subregional-based interdisciplinary Centers of Excellence in Ecology and Health Research and Training. Based at regional universities and/or research institutes but with very close links to the surrounding communities, these centers would have the following objectives:

  • Providing information based on good science to local communities about the links between environmental change and public health, including the factors that contribute to specific infectious disease outbreaks. The new research agenda must gather information on household and community perspectives about proposals for the use of their land. These perspectives are key to assessing the cost/benefit of a proposed project. Training local professionals in environmental, agricultural, and health science issues, with a particular focus on granting degrees in a new “trans”-discipline linking health and the environment, would be emphasized.
  • Acting as centers of integrated analysis of infectious disease emergence, incorporating perspectives and expertise from a variety of natural, social, and health sciences. Research activities would range from taxonomy of pathogens and vectors to identifying best practices for influencing changes in human behavior to reduce ecosystem and health risks.
  • Incorporating a “health impact assessment” as an important cross-sectorial decision-making tool in overall development planning (parallel to an environmental impact assessment), along with the need for doing more research.
  • Equipping professionals with the ability to recommend policy toward maintaining ecosystem function and promoting sustainable public health for future generations. For example, the link between forest fragmentation and Lyme disease risk could lead to preserving more intact tracts of forest habitat by planning “cluster” housing schemes.
Implementing research and policy programs.

In selecting areas for research and the placement of centers of excellence, it is important to choose geographically representative, highly diverse areas around the world. In addition, research projects should take place in regions or landscapes that have both well characterized and less characterized patterns of infectious disease emergence or transmission for comparison purposes. Local health and environment professionals, who are in the best position to understand local priorities, should make the choices within each region for initial research areas and sites.

Addressing trade-offs among environment, health, and development.

There are some inherent trade-offs when considering land-use change and health. They are ethical values, environmental versus health choices, and disparities in knowledge and economic class. Trade-offs are between short-term benefit and long-term damage. For example, draining swamps may reduce vector-borne disease hazards but also destroy the wetland ecosystem and its inherent services (e.g., water storage, water filtration, biologic productivity, and habitats for fish and wildlife). Research can help decision making by identifying and assessing trade-offs in different land-use-change scenarios. Balancing the diverse needs of people, livestock, wildlife, and the ecosystem will always be a prominent feature.

Conclusions

When considering issues of land use and infectious disease emergence, the public needs to be attentive to entire ecosystems rather than simply their local environs. Although we may not live within a certain environment, its health may indirectly affect our own. For example, intact forests support complex ecosystems and provide essential habitats for species that are specialized to those flora and that may be relevant to our health. If these complex relationships are disrupted, there may be unforeseen impacts on human health, as the above examples clearly demonstrate.

Encouraging initiatives.

Three new initiatives are rising to the challenges presented above. The first initiative, the Consortium for Conservation Medicine (CCM), was formed recently to address these health challenges at the interface of ecology, wildlife health, and public health (Figure 2). At its core, conservation medicine champions the integration of techniques and partnering of scientists from diverse disciplines, particularly veterinary medicine, conservation biology, and public health. Through the consortium, therefore, these experts work with educators, policy makers, and conservation program managers to devise approaches that improve the health of both species and humans simultaneously [more information is available from the CCM website (CCM 2004)].

The second initiative, the new international journal EcoHealth, focuses on the integration of knowledge at the intersection of ecologic and health sciences. The journal provides a gathering place for research and reviews that integrate the diverse knowledge of ecology, health, and sustainability, whether scientific, medical, local, or traditional. The journal will encourage development and innovation in methods and practice that link ecology and health, and it will ensure clear and concise presentation to facilitate practical and policy application [more information is available from the EcoHealth website (EcoHealth 2004)].

The third initiative, the MEA, is an international work program designed to meet the needs of decision makers and the public for scientific information concerning the consequences of ecosystem change for human health and well-being and for options in responding to those changes. This assessment was launched by United Nations Secretary-General Kofi Annan in June 2001 and will help to meet the assessment needs of international environmental forums, such as the Convention on Biological Diversity, the Convention to Combat Desertification, the Ramsar Convention on Wetlands, and the Convention on Migratory Species, as well as the needs of other users in the private sector and civil society [more information is available from the Millennium Assessment Working Groups website (Millennium Assessment Working Groups 2004)].

Challenges ahead.

As this working group of researchers continues to work on these topics, we face three challenges. First, strong trans-disciplinary research partnerships need to be forged to approach the research with the degree of creative thinking and comprehensiveness required by the nature of the problems. Second, if the work is to influence policy, the choice of questions and the research must be undertaken collaboratively with the local community and also through discussion with decision makers in government, industry, civil society, and other sectors. Third, investigators must consider how they can integrate their findings into the social, economic, and political dialogue on both the environment and health, globally and locally. As links between land use and health are elucidated, an informed public will more readily use such discoveries to better generate political will for effective change.

Figures and Tables

Figure 1 A systems model of land use change that affects public health. This model shows relationships between drivers of land use change and subsequent levels of environmental change and health consequences. Various levels of investigation and intervention are evident and range from specific risks factors and determinants of population vulnerability to larger institutional and economic activity.
Figure 2 The main elements converging under the Consortium for Conservation Medicine. Conservation medicine combines conservation biology, wildlife veterinary medicine, and public health. Adapted from Tabor (2002).

Table 1

SOURCE :

https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.6877

WHO ARE THE DIRECTORS OF THE SHOW?

The world seems be lost in a never ending state of chaos and confusion. Division is becoming the end goal. Usually that nonsense calms down after presidential elections but it hasn’t. It has been snowballing since Trump ran for office! I knew politicians weren’t going to agree with him necessarily but for Pete’s sake! ENOUGH is enough.

The ongoing demand for control has to stem from something much deeper or someone that is directing the show from behind the red velvet curtain. Things are so out of hand, that they have forgotten who they are. FREE PEOPLE! FREE AMERICANS! FREEDOM US WHAT THIS COUNTRY WAS FOUNDED ON! WE ARE NOT A SOCIALIST COUNTY? So what is going on?

The Great Reset

Let’s look at The Great Reset that we all keep hearing about. Here’s a little bit of information on this new agenda that is not actually very new at all come to find out.

The Great Reset is the name of the 50th annual meeting of the World Economic Forum (WEF), held in June 2020. It brought together high-profile business and political leaders, convened by Charles, Prince of Wales and the WEF, with the theme of rebuilding society and the economy following the COVID-19 pandemic.

WEF chief executive officer Klaus Schwab described three core components of the Great Reset:

International Monetary Fund director Kristalina Georgieva listed three key aspects of the sustainable response: green growth, smarter growth, and fairer growth.

1. the first involves creating conditions for a “stakeholder economy”;

2. the second component includes building in a more “resilient, equitable, and sustainable” way—based on environmental, social, and governance (ESG) metrics which would incorporate more green public infrastructure projects;

3. the third component is to “harness the innovations of the Fourth Industrial Revolution” for public good. In her keynote speech opening the dialogues,

The launch of The Great Reset

At the launch event for the Great Reset, Prince Charles listed key areas for action, similar to those listed in his Sustainable Markets Initiative, introduced in January 2020.

In June 2020, the theme of the January 2021 50th World Economic Forum Annual Meeting was announced as “The Great Reset”, connecting both in-person and online global leaders in Davos, Switzerland with a multi-stakeholder network in 400 cities around the world. The Great Reset was also to be the main theme of the WEF’s summit in Lucerne in May 2021, which was postponed to 2022.

The World Economic Forum generally suggests that a globalised world is best managed by a self-selected coalition of multinational corporations, governments and civil society organizations (CSOs). It sees periods of global instability – such as the financial crisis and the COVID-19 pandemic – as windows of opportunity to intensify its programmatic efforts. Some critics hence see the Great Reset as a continuation of the World Economic Forum’s strategy of focusing on connotated activist topics such as environmental protection and to disguise the organization’s true plutocratic goalssocial entrepreneurship

By mid-April 2020, against the backdrop of the COVID-19 pandemic, the COVID-19 recession, the 2020 Russia–Saudi Arabia oil price war and the resulting “collapse in oil prices”, the former Governor of the Bank of England, Mark Carney, described possible fundamental changes in an article in The Economist. Carney said that in a post-COVID world “stakeholder capitalism” will be tested as “companies will be judged by ‘what they did during the war,’ how they treated their employees, suppliers and customers, by who shared and who hoarded.” The “gulf between what markets value and what people value” will close.

In a post-COVID world, it is reasonable to expect that more people will want improvements in risk management, in social and medical safety nets, and will want more attention paid to scientific experts. This new hierarchy of values will call for a reset on the way we deal with climate change, which, like the pandemic, is a global phenomenon. No one can “self-isolate” from climate change so we all need to “act in advance and in solidarity”. In his 2020 BBC Reith Lectures, Carney developed his theme of value hierarchies as related to three crises—credit, COVID and climate.

According to a May 15, 2020 WEF article, COVID-19 offers an opportunity to “reset and reshape” the world in a way that is more aligned with the United Nations 2030

In June 2020, Klaus Schwab, who founded the World Economic Forum (WEF) in 1971 and is currently its CEO, described the three core components of the Great Reset.

Sustainable Development Goals (SDG), as climate change, inequality and poverty gained even greater urgency during the pandemic.

This includes resetting labour markets, as more people work remotely speeding up the process of the “future of work”. The reset will advance work already begun to prepare for the transition to the Fourth Industrial Revolution by upskilling and reskilling workers. Another post-COVID concern raised by the WEF is food security including the “risk of disruptions to food supply chains”, and the need forglobal policy coordination” to preventfood protectionism from becoming the post-pandemic new normal.”.

In her June 3, 2020 keynote address opening the Great Reset forum, a joint initiative of the WEC and the Prince of Wales, Kristalina Georgieva, Managing Director of the International Monetary Fund (IMF) said that there has been a “massive injection of fiscal stimulus to help countries deal with this crisis” and that it was of “paramount importance that this growth should lead to a greener, smarter, fairer world in the future”.

Georgieva listed three aspects of the Great Reset; green growth, smarter growth and fairer growth. Government investments and government incentives for private investors could “support low-carbon and climate-resilient growth” such as “planting mangroves, land restoration, reforestation or insulating buildings.” With low oil prices, the timing was right to eliminate fossil fuel subsidies and introduce carbon pricing to incentivize future investments. READ THAT AGAIN… INCENTIVE FOR FUTURE INVESTMENTS.

Are you getting the picture yet?

The COVID-19 pandemic presents an opportunity to shape an economic recovery and the future direction of global relations, economies and priorities.

In one of the Great Reset Dialogues, John Kerry and other members of a WEF dialogue discussed how to rebuild the “social contract” in a post-COVID world.

According to Prince Charles, the economic recovery must put the world on a path to sustainability, which would include carbon pricing. Prince Charles emphasized that the private sector would be the main drivers of the plan. The market should adapt to the current reality by aiming for fairer results, ensuring that investments are aimed at mutual progress including accelerating ecologically friendly investments, and to start a fourth industrial revolution, creating digital economic and public infrastructure. According to Klaus Schwab, they would not change the economic system, but rather improve it to what he considers to be “responsible capitalism”. HA!

Klaus SchwabGerman economist, founder of World Economic Forum

The Short Scoop on Klaus Martin Schwab

Schwab was born on 30 March 1938 and is a German engineer and economist best known as the founder and executive chairman of the World Economic Forum.

During the earlier years of his career, he served on a number of company boards, such as The Swatch Group, The Daily Mail Group, and Vontobel Holding. He is a former member of the steering committee of the Bilderberg Group

The Swiss radio and television corporation SRF mentioned the salary level of Klaus in the context of ongoing public contributions to the WEF and the fact that the Forum does not pay any federal taxes. Moreover, the former Frankfurter Allgemeine Zeitung journalist Jürgen Dunsch made the criticism that the WEF’s financial reports were not very transparent since neither income nor expenditure were broken down. I’m certain there are very good reasons for concerns about how he maintained his wealth over the years but that’s another dig for another day.

The Bilderberg Group Meetings are secret and by invitation only

The Bilderberg meeting (also known as the Bilderberg Group) is an annual conference established in 1954 to foster dialogue between Europe and North America. The group’s agenda, originally to prevent another world war, is now defined as bolstering a consensus around free market Western capitalism and its interests around the globe.

The conference was initiated by several people, including Polish politician-in-exile Józef Retinger who, concerned about the growth of anti-Americanism in Western Europe, proposed an international conference at which leaders from European countries and the United States would be brought together with the aim of promoting Atlanticismbetter understanding between the cultures of the United States and Western Europe to foster cooperation on political, economic, and defense issues.

Participants include political leaders, experts from industry, finance, academia, and the media, numbering between 120 and 150. Attendees are entitled to use information gained at meetings, but not attribute it to a named speaker. This is to encourage candid debate, while maintaining privacy – a provision that has fed conspiracy theories from both the left and right.

In 2002 in Them: Adventures with Extremists, author Jon Ronson wrote that the group has a small central office in Holland [sic] which each year decides what country will host the forthcoming meeting. The host country then has to book an entire hotel for four days, plus arrange catering, transport and security. To fund this, the host solicits donations from sympathetic corporations such as Barclays, Fiat Automobiles, GlaxoSmithKline, Heinz, Nokia and Xerox.

List of the Bilderberg Group Meetings Participants from the United States

Senators

Governors

Concerns about lobbying have arisen.

Ian Richardson sees Bilderberg as the transnational power elite, an integral, and to some extent critical, part of the existing system of global governance”, that is “not acting in the interests of the whole”. An article in The Guardian in June 2017 criticized the world view expressed in an agenda published by the Bilderberg group.

This should give you a general idea of what the Bilderberg Group is about but if you want to further your knowledge you can read more about the them, their meetings, goals and activities on their website at https://www.bilderbergmeetings.org

For a list of their FAQ’s go here

See also

WORLD ECONOMIC FORUM (WEF)

In the view of some critics, the WEF is exercising too much influence on global systems and institutions. The picture shows George Soros during a Davos session on redesigning the international monetary system.
George Soros speaking at the Word Economic Forum

In the view of some critics, the WEF is exercising too much influence on global systems and institutions. The picture shows George Soros during a Davos session on redesigning the international monetary system.

This brings me to the Plandemic

Since these “Globalist” seemed to be so concerned about the all of us normal folks and managed to sling trillions and trillions of money around like it grew on tree’s… Just who were the winners from lockdown nation?

And now that we have actual evidence of collateral damage from the lockdowns around the world why is almost the entire world protesting and demanding freedom? Why are we all in a bad way still and having such a difficult time getting back to normal? One would think that the current gas prices, food shortages in certain areas and the overall economic crisis would persuade even those on the far left who generally support the heavy hand of government to take a look around and question the people in power that are controlling the pathetic narrative. It would be apparent to a first grader they are all about complete control.

Big businesses scored a “$1.4 trillion payday” during the pandemic. Amazon, Apple, Facebook, Google and Microsoft increased their profits by 45% last year. “Wow, bring back more pandemics!” they must be shouting around the boardroom table.

Shutting down the economy hurt the poor the most and vastly widened the chasm between rich and poor. Lockdowns squashed small startup businesses, hurt low-income workers whose jobs were first in line to be destroyed, and devastated educational advances of children in the worst school districts.

For example, we have learned that high-achieving children did fine with remote learning. However, those who scored below average in school performance or from low-income families without computer skills tended to tune out and shut down online lessons completely. We know from teachers that as many as one-third of children rarely, if ever, even turned on a computer during the lockdowns. The long-term educational setbacks for these children as they grow to adult age could be devastating.

It’s not rocket science to figure out that the wealthy got wealthier! So, Just who were the BIG winners from lockdown nation? Let’s start with the corporate titans: Walmart, Google, Amazon, Walgreens, Apple, McDonald’s, Pfizer, Goldman Sachs, etc. THEY’ were rewarded with the designation of “essential” by the politicians. Their doors stayed open. They raked in dollars by the millions.

You can find all the information you need to confirm these facts. For instance there was is a headline from MarketWatch earlier this month: “Big Tech’s pandemic year produces mind-boggling financial results.” There was also was this nugget from the front page of The New York Times: “Wealth inequality is the highest since World War II.” George Soros, Bill Gates and Warren Buffett won the lottery.

I’m usually not a Big Tech or Big Pharma basher and actually like to see the stock market rise. It means people are making money. If these corporations make great products or can sell valuable services that people need, I am all for it! Yay for capitalism. Everyone’s happy.

But within the case of of our current situation, we see the hypocrisy of the left in the media shining big and bright. The left denounces inequality, but it embraces the policies that allow the uneven playing field. The entire situation baffles me to the core.

History lessons keep repeating Thema. They are like a skip on a vinyl record. Why on earth would anyone want to relive these deliberately concocted scenerios ridden with fear and oppression? What happened to faith in personal judgment. Big government creates economic unfairness. It never solves it.. When will people turn off the TV and stop believing the propaganda and LIVE LIFE?

World Economic Forum’s “Young Global Leaders”

World Economic Forum’s “Young Global Leaders”

Bill Gates and Justin Trudeau

By Jacob Nordangård

5 februari, 2022 Agenda 2030, Demokrati, ENGLISH, TeknokratiComments: 14

Through its Young Global Leaders program, the World Economic Forum has been instrumental in shaping a world order that undermines all democratic principles. For several decades, this program has nurtured compliant leaders acting as WEF agents in governments around the world. The consequences are far-reaching and may turn out to be devastating for humanity.

I have to say then I mention names like Mrs Merkel, even Vladimir Putin and so on… they all have been Young Global Leaders of The World Economic Forum. But what we are really proud of now with the young generation like Prime Minister Trudeau, President of Argentina and so on, is that we penetrate the cabinets… It is true in Argentina and it is true in France now…” (Klaus Schwab)

In 1992, Klaus Schwab and World Economic Forum launched a program initially called Global Leaders of Tomorrow. In 2004, this program was turned into the Forum for Young Global Leaders (which I cover in my book The Global Coup D’Etat) – a 5-year program of indoctrination into WEFs principles and goals. The aim was – and is – to find suitable future leaders for the emerging global society. The program has since its inception has included politicians, business leaders, royalty, journalists, performers and other cultural influencers who have excelled in their fields but have not yet turned 40 years of age (originally 43 in order to include Angela Merkel). It has since grown into an extensive global network of dedicated leaders with enormous resources and influence, all working to implement the technocratic plans of the World Economic Forum in their respective nations and fields.

The network creates a force for worldwide influence through the combination of the individual skills and resources of its members.

As Klaus Schwab says in the introductory quote, it has become very successful. Already in the first year, 1992, a number of highly influential candidates were elected.

Among 200 selected were global profiles such as:

  • Angela Merkel
  • Tony Blair
  • Nicolas Sarkozy
  • Bono
  • Richard Branson (Virgin)
  • Jorma Ollila (Shell Oil), and
  • José Manuel Barroso (President of the European Commission 2004–2014).[1]
  • Bill Gates (Global Leader of Tomorrow 1992)
  • Justin Trudeau (Young Global Leader, unknown class)

More examples of influential Young Global Leaders [2]:

  • Crown Princess Victoria of Sweden
  • Crown Prince Haakon of Norway
  • Crown Prince Fredrik of Denmark
  • Prince Jaime de Bourbon de Parme, Netherlands
  • Princess Reema Bint Bandar Al-Saud, Ambassador for Saudi-Arabia in USA
  • Jacinda Arden, Prime Minister, New Zeeland
  • Alexander De Croo, Prime Minister, Belgium
  • Emmanuel Macron, President, France
  • Sanna Marin, Prime Minister, Finland
  • Carlos Alvarado Quesada, President, Costa Rica
  • Faisal Alibrahim, Minister of Economy and Planning, Saudi Arabia
  • Shauna Aminath, Minister of Environment, Climate Change and Technology, Maldives
  • Ida Auken, MP, former Minister of Environment, Denmark (author to the infamous article “Welcome To 2030: I Own Nothing, Have No Privacy And Life Has Never Been Better”)
  • Annalena Baerbock, Minister of Foreign Affairs, Leader of Alliance 90/Die Grünen, Germany
  • Kamissa Camara, Minister of the Digital Economy and Planning, Mali
  • Ugyen Dorji, Minister of Domestic Affairs, Bhutan
  • Chrystia Freeland, Deputy Prime Minister and Minister of Finance, Canada
  • Martín Guzmán, Minister of Finance, Argentina
  • Muhammad Hammad Azhar, Minister of Energy, Pakistan
  • Paula Ingabire, Minister of Information and communications technology and Innovation, Rwanda
  • Ronald Lamola, Minister of Justice and Correctional Services, South Africa
  • Birgitta Ohlson, Minister for European Union Affairs 2010–2014, Sweden
  • Mona Sahlin, Party Leader of the Social Democrats 2007–2011, Sweden
  • Stav Shaffir, Leader of the Green Party, Israel
  • Vera Daves de Sousa, Minister of Finance, Angola
  • Leonardo Di Caprio, actor and Climate Activist
  • Mattias Klum, photographer and Environmentalist
  • Jack Ma, Founder of Alibaba
  • Larry Page, Founder of Google
  • Ricken Patel, Founder of Avaaz
  • David de Rothschild, adventurer and Environmentalist
  • Jimmy Wale, Founder of Wikipedia
  • Jacob Wallenberg, Chairman of Investor
  • Niklas Zennström, Founder of Skype
  • Mark Zuckerberg, Founder of Facebook

The purpose from the beginning has been to “identify and advance a future-oriented global agenda, focusing on issues at the intersection of the public and private sectors.” Public–Private Partnerships is one of the cornerstones of the World Economic Forum philosophy. That is, a merger between state and large companies (also known as corporativism) with the aim of solving global problems of in a more “effective” way. The choice of leaders clearly reflects this aspiration.

The Young Global Leaders group was initially instructed to identify the major challenges of the 21st century. These included peace, the environment, education, technology and health areas which these upcoming leaders could exploit politically, economically, and culturally in the new millennium.

Partners for Global Leaders of Tomorrow in 2000 were large global companies such as:

  • The Coca Cola Company
  • Ernst & Young
  • Volkswagen, and
  • BP Amoco

These could contribute to the agenda by “playing an active role in developing and implementing the concept of the GLT project. The partners can therefore actively participate in the development of GLT programs; representatives of the partner companies as well as their guests are invited to GLT meetings ..

Since the Global Leaders of Tomorrow was turned into Young Global Leaders 2004, partners such as:

  • The Bill & Melinda Gates Foundation
  • Google
  • JPMorganChase (with alumni from the program) have also participated as sponsors.

The ultimate consequence of both public–private partnerships and these target areas is the creation of a largely fascist social contract in which the individual has become subordinated to these powerful interests. Noble goals of creating a better world have also been kidnapped. This is especially evident in the context of the partnership between the WEF and the UN and the implementation of the global goals (Agenda 2030) through the application of the technologies of the Fourth Industrial Revolution.

This means that the democratic principles and division of power of the 20th century have largely been completely undermined and instead replaced by a new global class that shapes our common future based on their own interests. This has led to a de facto privatisation of both  national governments and international organisations, where lobbyists are no longer kept in the lobby but have moved into the seat of power, shaping policies directly affecting our lives. What this means has become particularly evident since the pandemic was declared in March 2020. In addition, leading multinational investment management corporations such as BlackRock, led by the World Economic Forum’s own Larry Fink, have constantly moved their positions forward.

German economist and journalist Ernst Wolff believes that many of the national leaders included in the Young Global Leader program have been selected for their willingness to carry out the tough agenda of lockdowns in recent years without asking any questions, and that their impending failure (as evidenced by in a growing dissatisfaction of the masses) will be used as an excuse to create a new form of Global Government where the old nation states become largely obsolete. A new global digital currency with Universal Basic Income (UBI) can then be gradually introduced to replace our doomed monetary system.[3] This conclusion partly coincides with my own. It is also supported by Paul Raskin‘s scenarios from The Great Transition Initiative on how  a totalitarian “New Earth Order” is established, to be replaced in the long run by a global democratic government (Earth Federation) with a World Constitution.[4]

The COVID-19 pandemic has underscored the catastrophic failure of an every-country-for-itself approach to public health, and national economic interests, rather than global needs, continue to dominate discussions of climate policy, paving the path toward climate chaos.

Under the tricameral World Parliament come the four main agencies of the Earth Federation government: the World Supreme Court system, the World Executive, the World Enforcement System, and the World Ombudsman.[5]Glen T. Martin, The Great Transition Requires the Earth Constitution

The vision is that a peaceful and harmonious world in balance is created through the establishment of a World Federation with a World Parliament, World Government and a World Court. These are ideas that have long circulated in Club of Rome and closely connected New Age circles. The question is how such a new global system of power would escape the fate of being kidnapped by the same interests that created our current corrupt and failing system? This is in view of those who support projects such as The Great Transition (initiated with start-up capital from Steven Rockefeller). What is happening is rather a method of taking us to their ultimate solution in the form of a global technocratic control system.

However, it is highly unlikely that this plan will succeed. Awareness is spreading like wildfire and the panic of the elite increases as their narrative crumbles and people become more and more immune to the propaganda. Hence all the inquisitors and “fact checkers” who diligently gatekeep the narrative and help steer public opinion in the “right” direction. They are surely to be trusted since, for example, David Roy Thomson, Chairman of the Thomson Reuters Corporation, is an alumni of Global Leaders of Tomorrow, class of 1993.

It is now time to take control of our own destinies and to avoid falling into new traps.

References

Thanks to investigative journalist Cory Morningstar for the clip that inspired this blog article. Follow her blog Wrong Kind of Green.

[1] World Economic Forum, GLT Class of 1993.pdf
[2] World Economic Forum, Young Global Leaders Community (searchable list over YGL alumni)
[3] Michael Lord, “Exposed: Klaus Schwab’s School For Covid Dictators, Plan for ‘Great Reset’“, RAIR Foundation, November 10, 2021
[4] Paul Raskin, Journey to Earthland: The Great Transition to Planetary Civilization.pdf, Tellus Institute, Boston, 2016
[5] Glen T. Martin, The Great Transition Requires the Earth Constitution“, Great Transition Initiative, November 2021

New Study on Ivermectin ‘Should Convince Any Naysayer’: Dr. Pierre Kory

According to Dr. Pierre Kory, a new study proves that ivermectin effectively prevents the transmission of COVID-19.

During a six-month study in 2020, residents of the Brazilian city of Itajai were given ivermectin upon request. Scientists found that the 100,000 participants in the study were 44 percent less likely to contract COVID-19. 

Cureus published  the peer-reviewed study on Jan. 15.

Dr. Pierre Kory, president of the Front Line COVID-19 Critical Care Alliance (FLCCC) told the Epoch Times the results of the study “should convince any naysayer,” adding, “what they found was astounding.”

The study, conducted between July 7 and Dec. 2, 2020, also showed that users of ivermectin enjoyed a statistically significant decrease in hospitalization and mortality.

The FDA and CDC have resisted authorizing the use of ivermectin. Some say their continued refusal to make the drug available is inexplicable, particularly after medical officials noted positive treatment results in India and Japan.

Pressure to allow ivermectin as a preventative or treatment medication for COVID in the United States is mounting. Prominent voices, such as Dr. Robert Malone, the inventor of the nine original mRNA vaccine patents, and podcaster Joe Rogan have encouraged political and medical officials to advocate its use.

Dr. Kory is astounded by the lack of reporting on the peer-reviewed study.

“You would think this would lead major headlines everywhere. And yet, nothing. And this is not new, this censorship of this highly effective science and evidence around repurposed drugs. The censoring of it, it’s not new, it’s just getting more and more absurd. And it has to stop,” he said.

Dr. Gideon Meyerowitz-Katz, an Australian epidemiologist, is not convinced. The Epoch Times reports he referred to Dr. Kory’s study as “a fairly simple example of observational research that you’d do on routine medical data” and suggested the controls for the study (designed to mitigate error) were “pretty inadequate given the purpose.”

The Food and Drug Administration has approved ivermectin for certain uses, but not for use against COVID-19. 

Many have complained that hospitals will not administer ivermectin. Others are concerned that pharmacies will not fill a prescription for ivermectin, even if prescribed by an in-network physician.